Inheritance & Variation of Traits, Inheritance 2: Genes and Growth (MS), Inheritance 2: Role of DNA (HS), Life Science, S&F 2: Body Systems (HS), S&F 3: Body Systems (MS), Structure and Function

Effects of Fat Loss on Inflammation

Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals

SUMMARY: This study looked at “normal weight female physique athletes” and how weight loss (specifically loss of visceral fat) decreased inflammation and increased enzymes that were beneficial for cardiovascular health. Results showed that weight loss upregulated genes that were contributed to anti-inflammation and removal of fats from arteries; however, when participants gained the weight back, genes that could cause cardiovascular harm were upregulated. Researchers concluded that exercising and limiting calories improves cardiovascular health.

LESSON COMMENTS: Topics that could benefit from this paper include: contents of blood, lipogenesis, function of the liver, and gene regulation. Could the results of this paper address/support some of the common viewpoints we have about exercise and health?

Sarin, H. V., Lee, J. H., Jauhiainen, M., Joensuu, A., Borodulin, K., Männistö, S., Jin, Z., Terwilliger, J. D., Isola, V., Ahtiainen, J. P., Häkkinen, K., Kristiansson, K., Hulmi, J. J., … Perola, M. (2019). Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals. Scientific reports, 9(1), 3450. doi:10.1038/s41598-019-40107-6