SUMMARY: This is a summary article of all the disorders and diseases that are correlated with gut microbiome disruption: Clostridium infections, inflammatory bowel disease, celiac disease, obesity, colon cancer, and autism spectrum disorder. For each disorder, the authors summarize the research that has been conducted to show a correlation between the gut microbiome and symptoms of the diseases. Mechanisms on how the gut microbiome could influence the immune, digestive, and nervous system are also discussed.
LESSON COMMENTS: The first section of this article talks about metabolites produced by gut microbiome and the ways these chemicals could affect the immune system and the nervous system. This article should be read in sections, with the teacher selecting the appropriate section for the class. Topics that this article can be used for include: interactions between the immune system and the gastrointestinal system, cause and effect versus correlation, nervous system, different parts of the innate and adaptive immune system, MHC I and II, and the diseases mentioned in this article.
Citation: Kho, Z. Y., & Lal, S. K. (2018). The Human Gut Microbiome – A Potential Controller of Wellness and Disease. Frontiers in microbiology, 9, 1835. doi:10.3389/fmicb.2018.01835