F&I 4: Gravity & Electrostatic Forces (HS), F&I 5: Force Fields (MS), Forces & Interactions, Life Science, Physical Science, S&F 1: Cells (MS), S&F 2: Cell Function (MS), S&P 1: Atoms & Molecules (MS), S&P 2: Investigating Electrical Force (HS), S&P 4: Molecule Traits (HS), Structure & Properties of Matter, Structure and Function

Nanoparticles Review for Antibiotic Resistant Bacteria

Promising Recent Strategies with Potential Clinical Translational Value to Combat Antibacterial Resistant Surge

SUMMARY: This article is a review (4 sections) of the different ways nanoparticles can be used to help fight antibacterial resistant bacteria. Section one is the introduction, which talks about where current research is with nanoparticles. Section two explains how nanoparticles interact with bacteria. Specifically, positively charged particles are attracted to the negatively charged bacteria cell wall. Section three explains three different ways that nanoparticles can be used to transport antibiotics to the bacteria; for example, delivering antibiotics directly into the macrophages (a place where some bacteria have evolved to hide). The last section explains how nanoparticles can be used on dressing and artificial implants to prevent bacteria growth.

LESSON COMMENTS: Great article to read during a lesson about cell organelles. Can be used for younger students to talk about the function of organelles (specifically cell walls and cell membranes). For older, more advanced students, this article is a good way to introduce them to the biochemistry of cell walls, liposomes, and cell membranes. Teachers can also use this to show the connection between physics (electrostatic forces) and biology (cell walls). The article is different from some of the other antibiotic resistance therapies in that it is more focused on biochemical structures of the bacteria.

Karmakar, P., & Gaitonde, V. (2019). Promising Recent Strategies with Potential Clinical Translational Value to Combat Antibacterial Resistant Surge. Medicines,6(1), 21. doi:10.3390/medicines601002